Least is an adjective that means the smallest amount:
Least是一个形容词,意思是“最小的;最少的(little的最高级)”。
We need the least amount of friction possible.
我们需要尽可能少的摩擦。
Lest
Lest is a conjunction that refers to averting or circumventing something
Lest则是一个连词,表示“回避或回避某事;唯恐,以免,只怕”
Memorial Day is a holiday to reflect on past wars lest we forget the soldiers who fought for our freedoms.
烈士纪念日是一个缅怀过去战争的节日,以免我们忘记那些为我们的自由而战的战士。
At Least
至少,起码
The English expression at least can be used before/with a verb, signifying that something can be done despite circumstances, or before/with a number/quantity, signifying a minimal quantity.