[12]screw up v.（常被动）（俚语）搞得乱七八糟；搅乱：Things are screwed up, as usual.事情跟平常一样糟。Screw up one’s courage 鼓起勇气

[Longman Dictionary of Contemporary English] someone who is screwed up has a lot of emotional problems because of bad or unhappy experiences in the past.